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Clinical Study 2

Corroborating Clinical Confirmation:
Patients with Joint Discomfort

Elderly woman suffering from pain in hand, arthritis old person and senior woman female suffering from pain at home

This second randomized, double-blind, placebo-controlled study explored how a 250mg dose of TamaFlex affected subjects with induced joint discomfort. Sixty (60) subjects (male and female 40-70 years old) were chosen and randomized for the baseline visit and three follow-up visits on days 5, 28, and 56, where the WOMAC self-assessment test was used as the primary efficacy measure.

Findings from Clinical Study 2

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Results found that, by day 5, the TamaFlex group started showing:

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Improvement in comfort

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Improvement in walking distance covered

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Improvement in stiffness

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Improvement in stair climbing time

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Improvement in physical activity

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Improvement in knee flexion scores

Of note with this study is that objective BioMarkers were tested and reviewed. Researchers also found significant reductions in TNF-α, hsCRP, and IL-6 levels in TamaFlex subjects, indicating the support of healthy inflammation systemically and specifically of the knee . TamaFlex also significantly reduced Matrix metalloproteinase-3 (MMP-3) activity, the compound that is involved with the breakdown of connective tissue. No serious adverse events were observed.

More TamaFlex Clinical Studies

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Clinical Study 1

A 90-Day Study with Healthy Participants

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Clinical Study 3

Confirms 5-day Joint Health Benefits: Patients With Mild Discomfort

* These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease

† Refers to normal inflammation from exercise or everyday activities.

Kare SK, Vinay V, Maresz K, Prisk V, Vik H. Tamarindus indica seed extract-based botanical compositions alleviate knee pain and improve joint function in mild-to-moderate osteoarthritis: a randomized, double-blind, placebo-controlled clinical study. Evid Based Complement Alternat Med. 2022 Jan 19;2022:2226139. doi: 10.1155/2022/2226139. PMID: 35096104; PMCID: PMC8791717.

Rao PS, Ramanjaneyulu YS, Prisk VR, Schurgers LJ. A Combination of Tamarindus indica seeds and Curcuma longa Rhizome extracts improves knee joint function and alleviates pain in non-arthritic adults following physical activity. Int J Med Sci. 2019 Jun 2;16(6):845-853. doi: 10.7150/ijms.32505. PMID:31337958; PMCID: PMC6643110.

Prasad N., Vinay V., and Srivastava A. Efficacy of a Proprietary Combination of Tamarindus indica Seeds and Curcuma longa Rhizome Extracts in Osteoarthritis: A Clinical Investigation. Food & Nutrition Research, vol. 67, 2023 June 20, doi: 10.29219/fnr.v67.9268.