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Clinical Study 3

Confirms 5-day Joint Health Benefits: Patients With Mild Discomfort

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The third human study has consistently confirmed the findings in the first two trials and again found improved physical performance. Yet a new by-product of this clinical strategy has been a clear improvement in life quality for participants – improvements in aerobic function, physical activity, strength, and endurance. To put it simply, participants were able to move more.

For this double-blind, randomized, placebo, and active comparator-controlled clinical study, one hundred fifty (150) subjects with mild to moderate joint discomfort were given 250mg of TamaFlex, 1000mg Active Comparator, or a placebo. By day 5, the TamaFlex group showed a significant reduction in knee discomfort. After 30 days of supplementation with TamaFlex, participants showed a significant reduction in joint discomfort and stiffness and improvement in their physical function and joint comfort.

Findings from Clinical Study 3

The third trial confirmed benefits with BioMarkers, including hsCRP and uCTX-II. Specifically, researchers measured uCTX-II levels in urine samples using commercial ELISA kits to quantify the protection against loss of cartilage in participants. The values were normalized with concentrations of creatinine in the urine samples.

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At the end of 30 days of supplementation, the TamaFlex group showed:

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Aerobic capacity and endurance of subjects with knee discomfort (as measured by absolute distance walked by subjects in a six-minute walk test (6MWT).

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Lower body strength, power, and physical function of participants (as witnessed by a significant increase in mean time covered during the stair climb test (SCT).

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Ability to perform a chair-stand test (seen in an increase in the number of repetitions in 30 seconds).

None of the subjects showed any adverse events throughout the study duration. All this with a plant-based ingredient that highlights the perfect marriage of ancient wisdom with modern science.

More TamaFlex Clinical Studies

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Clinical Study 1

A 90-Day Study with Healthy Participants

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Clinical Study 2

Corroborating Clinical Confirmation:
Patients with Joint Discomfort

* These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease
† Refers to normal inflammation from exercise or everyday activities.

Kare SK, Vinay V, Maresz K, Prisk V, Vik H. Tamarindus indica seed extract-based botanical compositions alleviate knee pain and improve joint function in mild-to-moderate osteoarthritis: a randomized, double-blind, placebo-controlled clinical study. Evid Based Complement Alternat Med. 2022 Jan 19;2022:2226139. doi: 10.1155/2022/2226139. PMID: 35096104; PMCID: PMC8791717.

Rao PS, Ramanjaneyulu YS, Prisk VR, Schurgers LJ. A Combination of Tamarindus indica seeds and Curcuma longa Rhizome extracts improves knee joint function and alleviates pain in non-arthritic adults following physical activity. Int J Med Sci. 2019 Jun 2;16(6):845-853. doi: 10.7150/ijms.32505. PMID:31337958; PMCID: PMC6643110.

Prasad N., Vinay V., and Srivastava A. Efficacy of a Proprietary Combination of Tamarindus indica Seeds and Curcuma longa Rhizome Extracts in Osteoarthritis: A Clinical Investigation. Food & Nutrition Research, vol. 67, 2023 June 20, doi: 10.29219/fnr.v67.9268.

* These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease

† Refers to normal inflammation from exercise or everyday activities.